在读学生和毕业生信息（数据为2011年之后）

医学博士，主任医师，教授，博士研究生导师。国家卫健委心律失常培训基地导师，中华医学会心电生理和起搏分会学组委员，中国生物医学工程学会心律分会起搏学组委员，辽宁省医学会心电生理与起搏学分会青年委员会委员兼秘书，大连市医学会心电生理与起搏学分会委员，大连市医师协会心律学专业委员会委员兼秘书。获全国首届“中青年心律失常防治菁英”科学研究类提名、“大连市医疗服务保障先进个人”、“大连市青年才俊”等称号。主持国家自然科学基金2项，省部级科研课题7项。发表论文30余篇。参编著作3部。主要从事心律失常的临床诊疗及科研工作，包括缓慢性心律失常的起搏治疗、慢性心功能不全的心脏再同步化治疗、快速心律失常的导管消融和药物治疗、晕厥及心源性猝死的防治。帮助省内多家医院开展起搏器植入技术。多次代表我院在全国及国际学术会议上进行学术报告和手术演示。

 

 

(1)    国家自然科学基金面上项目，82371587、《β-羟基丁酸通过促进柠檬酸合成酶表达调控线粒体功能抑制增龄性心房颤动的机制研究》。

(2)    辽宁省自然科学基金面上项目，2022-MS-336，《柠檬酸合酶（CS）通过调节线粒体复合物水平及能量代谢参与老年心房颤动发生的机制研究》。

(3)    辽宁省教育厅重点项目，LJKZ0852, 《免疫蛋白酶体亚基LMP10调节T淋巴细胞分化在高血压血管重构中的作用机制研究》。

(4)    国家自然科学基金青年基金，81500276、《免疫蛋白酶体β5i 通过调节线粒体功能保护心肌缺血/再灌注损伤的分子机制研究》。

(5)    辽宁省自然科学基金重点项目，20170540282，《免疫蛋白酶体β5i通过调控神经生长因子参与心肌梗死后心房颤动发生的机制研究》。

(6)    辽宁省教育厅科学研究项目，L2014355 、《X线修复交叉互补基因1（XRCC1）保护心脏缺血再灌注损伤的分子机制研究》。

(7)    辽宁省科学技术计划项目，2013225002、《Cystatin C在稳定易损动脉粥样硬化斑块中的作用及机制研究》。

(8)    辽宁省教育厅科学研究项目，L2011155 、《植物雌激素α-ZAL对血管内皮细胞氧化应激的保护作用及机制》。

 

1.       Zhang X, Wang N, Fu P, An Y, Sun F, Wang C, Han X, Zhang Y, Yu X（于晓红，共同通讯作者）, Liu Y. Dapagliflozin Attenuates HFpEF Remodeling and Dysfunction by Elevating β-Hydroxybutyrate-activated Citrate Synthase. J Cardiovasc Pharmacol. 2023 Aug 25. doi: 10.1097/FJC.0000000000001474. Epub ahead of print. PMID: 37643027.

2.       Jian He, Deng-yue Xu, Lu Wang, Xiao-Hong Yu（于晓红，共同通讯作者）. Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro. Front Pharmacol. 2023 Jan 4;13:1079251. doi: 10.3389/fphar.2022.1079251. PMID: 36686707; PMCID: PMC9846078. (IF=5.988)

3.       Kai-Wen Ren, Xiao-Hong Yu（于晓红，共同第一作者）, Yu-Hui Gu, Xin Xie, Yu Wang, Shi-hao Wang, Hui-Hua Li , Hai-Lian Bi. Cardiac Specific Knockdown Bhlhe40 Attenuates angiotensin II (Ang II)-induced Atrial Fibrillation in Mice. Frontiers in Cardiovascular Medicine.  2022 Oct 11;9:957903. doi: 10.3389/fcvm.2022.957903. eCollection 2022. (IF=5.846)

4.       Yuanjun Sun , Xiaohong Yu（于晓红，共同第一作者）, Xianjie Xiao, Shiyu Dai, Rongfeng Zhang, Zhongzhen Wang, Chengming Ma, Xiaomeng Yin, Lianjun Gao, Yanzong Yang, Yunlong Xia. Cardiomyopathy induced by premature ventricular contractions with ventricular escape beats in the compensatory pause. Medicine. 2022,101:34 :e30277. (IF=1.817)

5.       Sun Y, Yu XH（于晓红，共同第一作者）, Xiao XJ, Yin XM, Gao LJ, Zhang RF, Dai SY, Wang N, Zhang DD, Dong YX, Yang YZ, Xia YL. High efficiency and workflow of His bundle pacing and atrioventricular node ablation guided by three-dimensional mapping system. Pacing Clin Electrophysiol. 2020 Oct;43(10):1165-1172 .(IF=1.303)

6.       Li J, Wang S, Zhang YL, Bai J, Lin QY, Liu RS, Yu XH（于晓红，共同通讯作者）, Li HH. Immunoproteasome Subunit β5i Promotes Ang II (Angiotensin II)-Induced Atrial Fibrillation by Targeting ATRAP (Ang II Type I Receptor-Associated Protein) Degradation in Mice. Hypertension, 2019,73(1):92-101. (IF=7.713)

7.       Yang H, Li N, Song LN, Wang L, Tian C, Tang CS, Du J, Li HH, Yu XH（于晓红，通讯作者), Wang HX. Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways. Apoptosis, 2015, 20(4):512-22. (IF=3.592)

8.       Yu X（于晓红）, Liu J, Zhu H, Xia Y, Gao L, Li Z, Jia N, Shen W, Yang Y, Niu W. An interactive association of advanced glycation end-product receptor gene four common polymorphisms with coronary artery disease in northeastern Han Chinese. PLoS One, 2013, 8(10):e76966. (IF=3.534)

9.    Yu X（于晓红）, Liu J, Zhu H, Xia Y, Gao L, Dong Y, Jia N, Shen W, Yang Y, Niu W. Synergistic association of DNA repair relevant gene polymorphisms with the risk of coronary artery disease in northeastern Han Chinese. Thromb Res, 2014,133(2):229-34. (IF=2.427)

10.    Gu YH, Ren KW, Wang Y, Wang SH, Yu XH（于晓红）, Xu LW, Li HH, Bi HL. Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice. Front Pharmacol. 2022 Oct 25;13:1021361. doi: 10.3389/fphar.2022.1021361. PMID: 36386139. (IF=5.988)

11.    Yang M, Zhang R, Tang H, Li G, Guan X, Yang Y, Sun Y, Xiao X, Yu X（于晓红）, Yin X, Dong Y, Gao L, Xia Y, Yang Y. E/E' Is a New Independent Predictor of Recovered Ejection Fraction in Patients With Systolic Heart Failure Undergoing Ablation for Atrial Fibrillation. Front Cardiovasc Med. 2022 Jan 13;8:707996. doi: 10.3389/fcvm.2021.707996. PMID: 35096987 (IF=5.846)

12.    Zhang R, Wang Y, Yang M, Yang Y, Wang Z, Yin X, Dong Y, Yu X（于晓红）, Xiao X, Gao L, Xia Y. Risk Stratification for Atrial Fibrillation and Outcomes in Tachycardia-Bradycardia Syndrome: Ablation vs. Pacing. Front Cardiovasc Med. 2021 Jun 8;8:674471. doi: 10.3389/fcvm.2021.674471. PMID: 34169100; PMCID: PMC8217458. (IF=6.05)

13.    Liu F, Sun W, Li Y, Sun Y, Yu X（于晓红）, Yin X, Xia Y. Low-Level Stimulation and Ethanol Ablation of the Vein of Marshall Prevent the Vagal-Mediated AF. Front Cardiovasc Med. 2021 May 5;8:675485. doi: 10.3389/fcvm.2021.675485. PMID: 34026877; PMCID: PMC8131864. (IF=6.05)

14.    Zhang RF, Ma CM, Wang N, Yang MH, Li WW, Yin XM, Dong YX, Yu XH（于晓红）, Xiao XJ, Xia YL, Gao LJ. Appropriate intraprocedural initial heparin dosing in patients undergoing catheter ablation for atrial fibrillation receiving uninterrupted non-vitamin-K antagonist oral anticoagulant treatment. BMC Cardiovasc Disord. 2021 Apr 27;21(1):214. doi: 10.1186/s12872-021-02032-3. PMID: 33906609; PMCID: PMC8077881. (IF=2.174)

15.    Ma C, Yin X, Xia Y, Sun J, Dai S, Gao L, Xiao X, Sun Y, Zhang R, Dong Y, Wang Z, Yu X（于晓红）. High-power, short-duration ablation in the coronary sinus: clinical cases and preliminary observations on swine hearts. J Interv Card Electrophysiol. 2022 Mar;63(2):311-321. doi: 10.1007/s10840-021-00994-0.  (IF=1.759)

16.    Ma C, Yin X, Xia Y, Li W, Gao L, Dai S, Yu X（于晓红）. Frequent inappropriate implantable cardioverter defibrillator therapy was determined to be dual atrioventricular nodal non-reentrant tachycardia: A case report. Medicine (Baltimore). 2021 Apr 9;100(14):e25370. doi: 10.1097/MD.0000000000025370. PMID: 33832121; PMCID: PMC8036121. (IF=1.817)

17.    Sun YJ, Yin XM, Cong T, Gao LJ, Chang D, Xiao XJ, Sun QB, Zhang RF, Yu XH（于晓红）, Dong YX, Yang YZ, Xia YL. Comparison of cryoballoon ablation for atrial fibrillation guided by real-time three-dimensional transesophageal echocardiography vs. contrast agent injection. Chin Med J (Engl). 2019 Feb 5;132(3):285-293. doi: 10.1097/CM9.0000000000000076. PMID: 30681494; PMCID: PMC6595802. (IF=1.585)

18.    Sun Y, Xiao X, Yin X, Gao L, Yu X（于晓红）, Zhang R, Wang Z, Dai S, Yang Y, Xia Y. Impact of baseline impedance of pulmonary vein antrum on success of catheter ablation for paroxysmal atrial fibrillation guided by ablation index. BMC Cardiovasc Disord. 2022 Apr 19;22(1):179. doi: 10.1186/s12872-022-02530-y. PMID: 35439961 (IF=2.174)

19.    Xu J, Yu X（于晓红）, Huang C, Qin R, Peng F, Lin J, Niu W. Association of 5 well-defined polymorphisms in the gene encoding transforming growth factor-β1 with coronary artery disease among Chinese patients with hypertension. Angiology, 2015,66(7):652-658. (IF=2.37)

20.    Han QY, Wang HX, Liu XH, Guo CX, Hua Q, Yu XH（于晓红）, Li N, Yang YZ, Du J, Xia YL, Li HH. Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction. Clin Sci(Lond), 2015 ,128(11):751-60. (IF=5.629)

21.    Liu Y, Niu XH, Yin X, Liu YJ, Han C, Yang J, Huang X, Yu X（于晓红）, Gao L, Yang YZ, Xia YL, Li HH. Elevated Circulating Fibrocytes Is a Marker of Left Atrial Fibrosis and Recurrence of Persistent Atrial Fibrillation. J Am Heart Assoc,  2018,13;7(6): e008083. (IF=4.66)

22.    Dang MQ, Zhao XC, Lai S, Wang X, Wang L, Zhang YL, Liu Y, Yu XH（于晓红）, Liu Y, Li HH, Xia YL. Gene expression profile in the early stage of angiotensin II-induced cardiac remodeling: a time series microarray study in a mouse model. Cell Physiol Biochem, 2015,35(2):467-76. (IF=3.55)

23.    Wang Y, Du F, Zhao H, Yu X（于晓红）, Liu J, Xiao Y, Lu C, Li X, Wang Y, Wang B, Niu W. Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients. PLoS One, 2014,9(7): e103161. (IF=3.534)

24.    Sun YJ, Yin XM, Cong T, Gao LJ, Chang D, Xiao XJ, Sun QB, Zhang RF, Yu XH（于晓红）, Dong YX, Yang YZ, Xia YL. Comparison of cryoballoon ablation for atrial fibrillation guided by real-time three-dimensional transesophageal echocardiography vs. contrast agent injection. Chin Med J (Engl). 2019,132(3):285-293. (IF=1.16)